Periodontitis and Sleep Disordered Breathing in the Hispanic Community Health Study/Study of Latinos
Identifieur interne : 000246 ( Pmc/Curation ); précédent : 000245; suivant : 000247Periodontitis and Sleep Disordered Breathing in the Hispanic Community Health Study/Study of Latinos
Auteurs : Anne E. Sanders [États-Unis] ; Greg K. Essick [États-Unis] ; James D. Beck [États-Unis] ; Jianwen Cai [États-Unis] ; Shirley Beaver [États-Unis] ; Tracy L. Finlayson [États-Unis] ; Phyllis C. Zee [États-Unis] ; Jose S. Loredo [États-Unis] ; Alberto R. Ramos [États-Unis] ; Richard H. Singer [États-Unis] ; Monik C. Jimenez [États-Unis] ; Janice M. Barnhart [États-Unis] ; Susan Redline [États-Unis]Source :
- Sleep [ 0161-8105 ] ; 2015.
Abstract
To investigate the association between sleep disordered breathing (SDB) and severe chronic periodontitis.
Cross-sectional data analysis from the Hispanic Community Health Study/Study of Latinos.
Community-based setting with probability sampling from four urban US communities.
12,469 adults aged 18–74 y.
None.
Severe chronic periodontitis was defined using the Centers for Disease Control and Prevention/American Academy of Periodontology case classification based on full-mouth periodontal assessments performed by calibrated dentists. SDB was evaluated in standardized home sleep tests, and defined as the number of apnea plus hypopnea events associated with ≥ 3% desaturation, per hour of estimated sleep. SDB was quantified using categories of the apnea-hypopnea index (AHI): 0.0 events (nonapneic); 0.1–4.9 (subclinical); 5.0–14.9 (mild); and ≥ 15 (moderate/severe). Covariates were demographic characteristics and established periodontitis risk factors. C-reactive protein was a potential explanatory variable. Using survey estimation, multivariable binary logistic regression estimated odds ratios (OR) and 95% confidence limits (CL). Following adjustment for confounding, the SDB and periodontitis relationship remained statistically significant, but was attenuated in strength and no longer dose-response. Compared with the nonapneic referent, adjusted odds of severe periodontitis were 40% higher with subclinical SDB (OR = 1.4, 95% CL: 1.0, 1.9), 60% higher with mild SDB (OR = 1.6, 95% CL: 1.1, 2.2) and 50% higher with moderate/severe SDB (OR = 1.5, 95% CL: 1.0, 2.3) demonstrating an independent association between SDB and severe periodontitis.
This study identifies a novel association between mild sleep disordered breathing and periodontitis that was most pronounced in young adults.
Sanders AE, Essick GK, Beck JD, Cai J, Beaver S, Finlayson TL, Zee PC, Loredo JS, Ramos AR, Singer RH, Jimenez MC, Barhart JM, Redline S. Periodontitis and sleep disordered breathing in the Hispanic Community Health Study/Study of Latinos.
Url:
DOI: 10.5665/sleep.4890
PubMed: 25669183
PubMed Central: 4507724
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Singer</name><affiliation wicri:level="2"><nlm:aff id="aff8">Department of Neurology, University of Miami, Miller School of Medicine, Miami, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, University of Miami, Miller School of Medicine, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Jimenez, Monik C" sort="Jimenez, Monik C" uniqKey="Jimenez M" first="Monik C." last="Jimenez">Monik C. 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Barnhart</name><affiliation wicri:level="2"><nlm:aff id="aff10">Albert Einstein College of Medicine of Yeshiva University, Bronx, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Albert Einstein College of Medicine of Yeshiva University, Bronx</wicri:cityArea></affiliation></author><author><name sortKey="Redline, Susan" sort="Redline, Susan" uniqKey="Redline S" first="Susan" last="Redline">Susan Redline</name><affiliation wicri:level="2"><nlm:aff id="aff11">Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25669183</idno><idno type="pmc">4507724</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507724</idno><idno type="RBID">PMC:4507724</idno><idno type="doi">10.5665/sleep.4890</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000246</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000246</idno><idno type="wicri:Area/Pmc/Curation">000246</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000246</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Periodontitis and Sleep Disordered Breathing in the Hispanic Community Health Study/Study of Latinos</title><author><name sortKey="Sanders, Anne E" sort="Sanders, Anne E" uniqKey="Sanders A" first="Anne E." last="Sanders">Anne E. Sanders</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Dental Ecology, University of North Carolina, Chapel Hill, NC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Dental Ecology, University of North Carolina, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Essick, Greg K" sort="Essick, Greg K" uniqKey="Essick G" first="Greg K." last="Essick">Greg K. Essick</name><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Prosthodontics, Center for Pain Research and Innovation, University of North Carolina, Chapel Hill, NC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Prosthodontics, Center for Pain Research and Innovation, University of North Carolina, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Beck, James D" sort="Beck, James D" uniqKey="Beck J" first="James D." last="Beck">James D. Beck</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Dental Ecology, University of North Carolina, Chapel Hill, NC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Dental Ecology, University of North Carolina, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Cai, Jianwen" sort="Cai, Jianwen" uniqKey="Cai J" first="Jianwen" last="Cai">Jianwen Cai</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Biostatistics, University of North Carolina, Chapel Hill, NC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Biostatistics, University of North Carolina, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Beaver, Shirley" sort="Beaver, Shirley" uniqKey="Beaver S" first="Shirley" last="Beaver">Shirley Beaver</name><affiliation wicri:level="2"><nlm:aff id="aff4">Sanford-Brown College, Skokie, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Sanford-Brown College, Skokie</wicri:cityArea></affiliation></author><author><name sortKey="Finlayson, Tracy L" sort="Finlayson, Tracy L" uniqKey="Finlayson T" first="Tracy L." last="Finlayson">Tracy L. Finlayson</name><affiliation wicri:level="2"><nlm:aff id="aff5">Graduate School of Public Health, San Diego State University, San Diego, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Graduate School of Public Health, San Diego State University, San Diego</wicri:cityArea></affiliation></author><author><name sortKey="Zee, Phyllis C" sort="Zee, Phyllis C" uniqKey="Zee P" first="Phyllis C." last="Zee">Phyllis C. Zee</name><affiliation wicri:level="2"><nlm:aff id="aff6">Center for Sleep and Circadian Biology, Northwestern University, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Center for Sleep and Circadian Biology, Northwestern University, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Loredo, Jose S" sort="Loredo, Jose S" uniqKey="Loredo J" first="Jose S." last="Loredo">Jose S. Loredo</name><affiliation wicri:level="2"><nlm:aff id="aff7">Sleep Medicine Center and VA Pulmonary Sleep Disorders laboratory, University of California San Diego School of Medicine, San Diego, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Sleep Medicine Center and VA Pulmonary Sleep Disorders laboratory, University of California San Diego School of Medicine, San Diego</wicri:cityArea></affiliation></author><author><name sortKey="Ramos, Alberto R" sort="Ramos, Alberto R" uniqKey="Ramos A" first="Alberto R." last="Ramos">Alberto R. Ramos</name><affiliation wicri:level="2"><nlm:aff id="aff7">Sleep Medicine Center and VA Pulmonary Sleep Disorders laboratory, University of California San Diego School of Medicine, San Diego, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Sleep Medicine Center and VA Pulmonary Sleep Disorders laboratory, University of California San Diego School of Medicine, San Diego</wicri:cityArea></affiliation></author><author><name sortKey="Singer, Richard H" sort="Singer, Richard H" uniqKey="Singer R" first="Richard H." last="Singer">Richard H. Singer</name><affiliation wicri:level="2"><nlm:aff id="aff8">Department of Neurology, University of Miami, Miller School of Medicine, Miami, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, University of Miami, Miller School of Medicine, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Jimenez, Monik C" sort="Jimenez, Monik C" uniqKey="Jimenez M" first="Monik C." last="Jimenez">Monik C. Jimenez</name><affiliation wicri:level="2"><nlm:aff id="aff9">Department of Public Health Sciences, University of Miami, Miller School of Medicine, Miami, FL and Brigham and Women's Hospital Harvard Medical School, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Public Health Sciences, University of Miami, Miller School of Medicine, Miami, FL and Brigham and Women's Hospital Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Barnhart, Janice M" sort="Barnhart, Janice M" uniqKey="Barnhart J" first="Janice M." last="Barnhart">Janice M. Barnhart</name><affiliation wicri:level="2"><nlm:aff id="aff10">Albert Einstein College of Medicine of Yeshiva University, Bronx, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Albert Einstein College of Medicine of Yeshiva University, Bronx</wicri:cityArea></affiliation></author><author><name sortKey="Redline, Susan" sort="Redline, Susan" uniqKey="Redline S" first="Susan" last="Redline">Susan Redline</name><affiliation wicri:level="2"><nlm:aff id="aff11">Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston</wicri:cityArea></affiliation></author></analytic><series><title level="j">Sleep</title><idno type="ISSN">0161-8105</idno><idno type="eISSN">1550-9109</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Study Objectives:</title><p>To investigate the association between sleep disordered breathing (SDB) and severe chronic periodontitis.</p></sec><sec><title>Design:</title><p>Cross-sectional data analysis from the Hispanic Community Health Study/Study of Latinos.</p></sec><sec><title>Setting:</title><p>Community-based setting with probability sampling from four urban US communities.</p></sec><sec><title>Participants:</title><p>12,469 adults aged 18–74 y.</p></sec><sec><title>Interventions:</title><p>None.</p></sec><sec><title>Measurements and Results:</title><p>Severe chronic periodontitis was defined using the Centers for Disease Control and Prevention/American Academy of Periodontology case classification based on full-mouth periodontal assessments performed by calibrated dentists. SDB was evaluated in standardized home sleep tests, and defined as the number of apnea plus hypopnea events associated with ≥ 3% desaturation, per hour of estimated sleep. SDB was quantified using categories of the apnea-hypopnea index (AHI): 0.0 events (nonapneic); 0.1–4.9 (subclinical); 5.0–14.9 (mild); and ≥ 15 (moderate/severe). Covariates were demographic characteristics and established periodontitis risk factors. C-reactive protein was a potential explanatory variable. Using survey estimation, multivariable binary logistic regression estimated odds ratios (OR) and 95% confidence limits (CL). Following adjustment for confounding, the SDB and periodontitis relationship remained statistically significant, but was attenuated in strength and no longer dose-response. Compared with the nonapneic referent, adjusted odds of severe periodontitis were 40% higher with subclinical SDB (OR = 1.4, 95% CL: 1.0, 1.9), 60% higher with mild SDB (OR = 1.6, 95% CL: 1.1, 2.2) and 50% higher with moderate/severe SDB (OR = 1.5, 95% CL: 1.0, 2.3) demonstrating an independent association between SDB and severe periodontitis.</p></sec><sec><title>Conclusions:</title><p>This study identifies a novel association between mild sleep disordered breathing and periodontitis that was most pronounced in young adults.</p></sec><sec><title>Citation:</title><p>Sanders AE, Essick GK, Beck JD, Cai J, Beaver S, Finlayson TL, Zee PC, Loredo JS, Ramos AR, Singer RH, Jimenez MC, Barhart JM, Redline S. Periodontitis and sleep disordered breathing in the Hispanic Community Health Study/Study of Latinos. <italic>SLEEP</italic> 2015;38(8):1195–1203.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Sleep</journal-id><journal-id journal-id-type="iso-abbrev">Sleep</journal-id><journal-id journal-id-type="publisher-id">Sleep</journal-id><journal-title-group><journal-title>Sleep</journal-title></journal-title-group><issn pub-type="ppub">0161-8105</issn><issn pub-type="epub">1550-9109</issn><publisher><publisher-name>Associated Professional Sleep Societies, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25669183</article-id><article-id pub-id-type="pmc">4507724</article-id><article-id pub-id-type="publisher-id">sp-00427-14</article-id><article-id pub-id-type="doi">10.5665/sleep.4890</article-id><article-categories><subj-group subj-group-type="heading"><subject>Periodontitis and SDB in the Hispanic Community Health Study/Study of Latinos</subject></subj-group></article-categories><title-group><article-title>Periodontitis and Sleep Disordered Breathing in the Hispanic Community Health Study/Study of Latinos</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Sanders</surname><given-names>Anne E.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Essick</surname><given-names>Greg K.</given-names></name><degrees>DDS, PhD</degrees><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Beck</surname><given-names>James D.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cai</surname><given-names>Jianwen</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Beaver</surname><given-names>Shirley</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Finlayson</surname><given-names>Tracy L.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zee</surname><given-names>Phyllis C.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Loredo</surname><given-names>Jose S.</given-names></name><degrees>MD, MPH</degrees><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ramos</surname><given-names>Alberto R.</given-names></name><degrees>MD, MSPH</degrees><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Singer</surname><given-names>Richard H.</given-names></name><degrees>DMD, MS</degrees><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jimenez</surname><given-names>Monik C.</given-names></name><degrees>ScD</degrees><xref ref-type="aff" rid="aff9"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Barnhart</surname><given-names>Janice M.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff10"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Redline</surname><given-names>Susan</given-names></name><degrees>MD, MPH</degrees><xref ref-type="aff" rid="aff11"><sup>11</sup></xref></contrib><aff id="aff1"><label>1</label>Department of Dental Ecology, University of North Carolina, Chapel Hill, NC</aff><aff id="aff2"><label>2</label>Department of Prosthodontics, Center for Pain Research and Innovation, University of North Carolina, Chapel Hill, NC</aff><aff id="aff3"><label>3</label>Department of Biostatistics, University of North Carolina, Chapel Hill, NC</aff><aff id="aff4"><label>4</label>Sanford-Brown College, Skokie, IL</aff><aff id="aff5"><label>5</label>Graduate School of Public Health, San Diego State University, San Diego, CA</aff><aff id="aff6"><label>6</label>Center for Sleep and Circadian Biology, Northwestern University, Chicago, IL</aff><aff id="aff7"><label>7</label>Sleep Medicine Center and VA Pulmonary Sleep Disorders laboratory, University of California San Diego School of Medicine, San Diego, CA</aff><aff id="aff8"><label>8</label>Department of Neurology, University of Miami, Miller School of Medicine, Miami, FL</aff><aff id="aff9"><label>9</label>Department of Public Health Sciences, University of Miami, Miller School of Medicine, Miami, FL and Brigham and Women's Hospital Harvard Medical School, Boston, MA</aff><aff id="aff10"><label>10</label>Albert Einstein College of Medicine of Yeshiva University, Bronx, NY</aff><aff id="aff11"><label>11</label>Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA</aff></contrib-group><author-notes><corresp id="cor1">Address correspondence to: Dr. Anne E. Sanders, <addr-line>Koury Oral Health Sciences Building, Room 4502, CB# 7450, 385 South Columbia Street, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7450</addr-line><phone>(919) 537-3275</phone><email>anne_sanders@unc.edu</email></corresp></author-notes><pub-date pub-type="epub"><day>1</day><month>8</month><year>2015</year></pub-date><volume>38</volume><issue>8</issue><fpage>1195</fpage><lpage>1203</lpage><history><date date-type="received"><month>7</month><year>2014</year></date><date date-type="rev-recd"><month>12</month><year>2014</year></date><date date-type="accepted"><month>12</month><year>2014</year></date></history><permissions><copyright-statement>© 2015 Associated Professional Sleep Societies, LLC.</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract><sec><title>Study Objectives:</title><p>To investigate the association between sleep disordered breathing (SDB) and severe chronic periodontitis.</p></sec><sec><title>Design:</title><p>Cross-sectional data analysis from the Hispanic Community Health Study/Study of Latinos.</p></sec><sec><title>Setting:</title><p>Community-based setting with probability sampling from four urban US communities.</p></sec><sec><title>Participants:</title><p>12,469 adults aged 18–74 y.</p></sec><sec><title>Interventions:</title><p>None.</p></sec><sec><title>Measurements and Results:</title><p>Severe chronic periodontitis was defined using the Centers for Disease Control and Prevention/American Academy of Periodontology case classification based on full-mouth periodontal assessments performed by calibrated dentists. SDB was evaluated in standardized home sleep tests, and defined as the number of apnea plus hypopnea events associated with ≥ 3% desaturation, per hour of estimated sleep. SDB was quantified using categories of the apnea-hypopnea index (AHI): 0.0 events (nonapneic); 0.1–4.9 (subclinical); 5.0–14.9 (mild); and ≥ 15 (moderate/severe). Covariates were demographic characteristics and established periodontitis risk factors. C-reactive protein was a potential explanatory variable. Using survey estimation, multivariable binary logistic regression estimated odds ratios (OR) and 95% confidence limits (CL). Following adjustment for confounding, the SDB and periodontitis relationship remained statistically significant, but was attenuated in strength and no longer dose-response. Compared with the nonapneic referent, adjusted odds of severe periodontitis were 40% higher with subclinical SDB (OR = 1.4, 95% CL: 1.0, 1.9), 60% higher with mild SDB (OR = 1.6, 95% CL: 1.1, 2.2) and 50% higher with moderate/severe SDB (OR = 1.5, 95% CL: 1.0, 2.3) demonstrating an independent association between SDB and severe periodontitis.</p></sec><sec><title>Conclusions:</title><p>This study identifies a novel association between mild sleep disordered breathing and periodontitis that was most pronounced in young adults.</p></sec><sec><title>Citation:</title><p>Sanders AE, Essick GK, Beck JD, Cai J, Beaver S, Finlayson TL, Zee PC, Loredo JS, Ramos AR, Singer RH, Jimenez MC, Barhart JM, Redline S. Periodontitis and sleep disordered breathing in the Hispanic Community Health Study/Study of Latinos. <italic>SLEEP</italic> 2015;38(8):1195–1203.</p></sec></abstract><kwd-group><kwd>apnea-hypopnea index</kwd><kwd>periodontal disease</kwd><kwd>Hispanic</kwd><kwd>survey</kwd><kwd>epidemiology</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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